Study: Open-label, randomized phase II trial Metastatic colorectal cancer, refractory or intolerant to fluoropyrimidines, irinotecan, oxaliplatin, and anti-EGFR (for RAS WT) Trifluridine/tipiracil with (n=47) vs. without bevacizumab (n=46) Efficacy: Disease
Study: Open-label, randomized phase II trial (DESTINY-Gastric01) Her2-positive gastric/GE junction adenoCa pts who received >=2 previous regimens including 5-FU, platinum, and trastuzumab Trastuzumab deruxtecan (n= 125) vs. physician’s choice of
Study: Open-label, randomized phase III trial (ANDROMEDA) Newly diagnosed light chain amyloidosis with >=1 affected organ CyBorD with or without subQ daratumumab (n= 195 and 193, respectively) Efficacy: Hematologic CR:
Study: Open-label, randomized phase II trial Metastatic or unresectable colorectal cancer with bRAF-V600E mutation. Received one or more systemic therapy before Irinotecan – cetuximab + placebo (n=50) vs. Irinotecan –
Study: Open-label, phase 3 trial (BOSTON) Multiple myeloma progressed on or after last treatment regimen, previously received 1-3 regimens Selinexor – wkly bortezomib – dexamethasone (n=195) vs. twice wkly bortezomib
Study: Open-label, phase 3 trial Candidates for >=1 yr of continuous androgen-deprivation therapy Oral Relugolix (n=622) vs. leuprolide (n=308) Efficacy: Sustained testosterone suppression: 96.7% vs. 88.8% (non-inferior) Probability of castration
Study: Open-label phase 3 trial Previously untreated metastatic MSI-H-dMMR colorectal cancer Pembrolizumab 200 mg q21 (n=153) vs. investigator’s choice of chemo (n=154) Chemo: mFOLFOX6 or FOLFIRI alone or with bevacizumab
Study: Phase I/II, single arm (ARROW trial) Advanced RET mutation-positive RAI-refractory thyroid cancer (n=9, all had papillary thyroid cancer) Efficacy: ORR: 89% (52% – 100%), all PR Duration of response
Study: Phase I/II, single arm (ARROW trial) Advanced RET mutation-positive medullary thyroid cancer (MTC, n= 79). Previously treated with cabozantinib or vandetanib or both (n=55) Efficacy: ORR: 65% (overall, 53%-75%),
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