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New Drug: Cabozantinib for differentiated thyroid cancer

New Drug: Cabozantinib for differentiated thyroid cancer
  • Double-blind, randomized Phase III trial (COSMIC-311)
  • RAI-refractory differentiated thyroid cancer pts with prior lenvatinib or sorafenib
  • Cabozantinib 60 mg daily vs. placebo
  • ORR: 18% vs. 0%
  • Median PFS: 11.0 vs. 1.9 mos (HR: 0.22 [0.13-0.36])
  • OS numerically improved
  • Any grade AEs: diarrhea (51% vs. 3%), hand-foot skin (46% vs. none), hypertension (28% vs. 5%), fatigue (27% vs. 8%), nausea (24% vs. 2%)

J Clin Oncol. 2021;39:suppl 6001

Brose MS, et al. Cabozantinib versus placebo in patients with radioiodine-refractory differentiated thyroid cancer who have progressed after prior VEGFR-targeted therapy: Results from the phase 3 COSMIC-311 trial

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Altai Chemo Planner employs Altai Protocol Library that includes over 1000 chemotherapy protocols for both Hematology and Oncology. You can find major guidelines' protocols, parenteral, and oral, in the library. Altai Protocol Library is frequently and regularly updated.

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