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New Drug: Dostarlimab-gxly for dMMR endometrial cancer

New Drug: Dostarlimab-gxly for dMMR endometrial cancer
Study:
  • Multicenter, multicohort, open-abel trial (GARNET)
  • dMMR recurrent or advanced endometrial cancer who had progressed on or after a platinum-containing regimen
  • Dostarlimab-gxly q21 (n=141)
Efficacy:
  • ORR: 45.4% [37.0-54.0]; CR: 15.6%; PR:29.8%
  • 12 mos DOR: 85.9%
  • 24 mos DOR: 54.7%
Safety:
  • Any grade AEs: Asthenia (40%), diarrhea (25%), anemia (25%), neutropenia (12%), skin rash (14%).

BMJ 2022, 10 (1)

Oaknin A et al. ¨Clinical activity and safety of the anti-PD-1 monoclonal antibody dostarlimab for patients with recurrent or advanced dMMR endometrial cancer l ¨

http://doi.org/10.1136/jitc-2021-003777

Reviewed by Elvin CHALABİYEV, MD on FEB 24, 2023

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