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New Drug: Lutetium-177-PSMA-617 for Metastatic Castration-Resistant Prostate Cancer - Altai Oncology
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New Drug: Lutetium-177-PSMA-617 for Metastatic Castration-Resistant Prostate Cancer

New Drug: Lutetium-177-PSMA-617 for Metastatic Castration-Resistant Prostate Cancer
Study:
  • International, open-label, phase 3 trial
  • Metastatic CRPC, previously treated with at least one androgen-receptor-pathway inhibitor and one or two taxane regimens
  • 177Lu-PSMA-617 (7.4 GBq every 6 weeks for four to six cycles) plus protocol-permitted standard care or standard care alone
Efficacy:
  • Imaging-based mPFS: 8.7 vs. 3.4 months [HR:0.40, 0.29-0.57; P<0.001]
  • mOS: 15.3 vs. 11.3 months; [HR, 0.62; 0.52-0.74; P<0.001]
Safety:
  • Grade >= 3 AEs: 52.7% vs 38.0%
  • All grades fatigue 43.1%, dry mouth 38.8%, nausea 35.3%, anemia 31.8% in the 177Lu-PSMA-617 group

N Engl J Med 2021 Sep 16;385(12):1091-1103.

Sartor, Oliver et al. “Lutetium-177-PSMA-617 for Metastatic Castration-Resistant Prostate Cancer.

https://doi.org/10.1056/nejmoa2107322

Reviewed by Hasan Çağrı Yıldırım, MD on May 30, 2022

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