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New Drug: Pacritinib for Myelofibrosis

New Drug: Pacritinib for Myelofibrosis
Study:
  • International, multicenter, randomized, double-blind trial (PERSIST-2)
  • Intermediate-1, intermediate-2, or high-risk disease myelofibrozis
  • Pacritinib 400 mg (n=75) vs pacritinib 200 mg BID (n=74) vs BAT (n=72
Efficacy:
  • >35% spleen volume reduction: 18% vs. 22% vs. 3% (p=0.001)
  • Symptom reduction: 32% pacritinib BID vs. 14% BAT (p-0.01)
  • OS not statistically different between groups
Safety:
  • Non-hematologic AEs for pacritinib: gastrointestinal events, fatigue, peripheral edema, and dizziness
  • Non-hematologic AEs for BAT: abdominal pain, fatigue, diarrhea, and peripheral edema

JAMA Oncol. 2018;4(5):652-659

Pacritinib vs Best Available Therapy, Including Ruxolitinib, in Patients With Myelofibrosis

https://doi.org/10.1001/jamaoncol.2017.5818

Reviewed by Hasan Cagri Yildirim

Altai Chemo Planner

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Altai Chemo Planner employs Altai Protocol Library that includes over 1000 chemotherapy protocols for both Hematology and Oncology. You can find major guidelines' protocols, parenteral, and oral, in the library. Altai Protocol Library is frequently and regularly updated.

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