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New Drug: Relatlimab and Nivolumab in Advanced Melanoma

New Drug: Relatlimab and Nivolumab in Advanced Melanoma
Study:
  • Double-blind, randomized Phase II-III trial
  • Untreated metastatic or unresectable melanoma
  • Relatlimab and nivolumab vs nivolumab alone
Efficacy:
  • mPFS: 10.1 vs 4.6 mos (HR:0.75; P=0.006)
  • 12 months PFS: 47.7% vs 36.0%
  • PD L1<1 mPFS: 6.4 vs 2.9 mos (HR:0.66)
  • PD L1>=1 mPFS: 15.7 vs 14.7 mos (HR:0.95)
Safety:
  • Most AE’s: Hypothyroidism or thyroiditis (in 18.0% of the patients), rash (in 9.3%), diarrhea or colitis (in 6.8%) in combination arm
  • Grade >=3 increased levels of lipase (1.7%), ALT (1.4%), AST (1.4%), fatigue (1.1%) in combination arm

N Engl J Med. 2022 Jan 6;386(1):24-34.

Relatlimab and Nivolumab versus Nivolumab in Untreated Advanced Melanoma

https://doi.org/10.1056/NEJMoa2109970

Reviewed by Hasan Cagri Yildirim, MD on Mar 28, 2022

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