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New Drug: Sotorasib in KRAS p.G12C–Mutated Advanced Pancreatic Cancer

New Drug: Sotorasib in KRAS p.G12C–Mutated Advanced Pancreatic Cancer
Study:
  • International, multicenter, open-label, phase 1–2 trial
  • Pretreated, locally advanced or metastatic pancreatic cancer with KRAS p.G12C mutation
  • Sotorasib (n=38)
Efficacy:
  • ORR: 21% [10-37]
  • mDoR: 5.7 mos [1.6-NR]
  • mPFS: 4.0 mos [2.8 -5.6]
  • mOS: 6.9 mos [5.0-9.1]
Safety:
  • Grade≥3 AEs: diarrhea (5%).

N Engl J Med 2023; 388:33-43

Strickler J.H et al. ¨ Sotorasib in KRAS p.G12C–Mutated Advanced Pancreatic Cancer ¨

http://doi.org/10.1056/NEJMoa2208470

Reviewed by Elvin CHALABİYEV, MD on FEB 24, 2023

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