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New Drug: Tepotinib for NSCLC with MET Exon14 skipping mutations

New Drug: Tepotinib for NSCLC with MET Exon14 skipping mutations
Study:
  • Open-label phase II trial (VISION)
  • Locally advanced or metastatic NSCLC with MET exon 14 skipping mutations (N=99)
Efficacy:
  • ORR: 46% [36%-57%]
  • Median DoR: 11.1 mos [7.2 mos – NE]
  • Median PFS: 8.5 mos [5.1 – 11.0 mos]
Safety:
  • Grade 3-4 AEs: Edema (7%), pleural effusion (3%), increased amylase/lipase (3%)

N Engl J Med. Published online May 29, 2020

Paik PK, et al. Tepotinib in Non–Small-Cell Lung Cancer with MET Exon 14 Skipping Mutations

https://doi.org/10.1056/NEJMoa2004407

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