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New Drug: Umbralisib for relapsed/refractory follicular and marginal zone lymphoma

New Drug: Umbralisib for relapsed/refractory follicular and marginal zone lymphoma
Study:
  • Open-label phase II trial (UNITY-NHL), Umbralisib 800 mg PO daily
  • Relapsed/refractory disease, non-transplant candidates, had received anti-CD20
  • Marginal zone (n=69, MZL), Follicular (n=117, FL, non-grade IIIB)
Efficacy:
  • CR/ORR: 16%/49% in MZL, 5%/45% in FL
  • Median DoR: NR [10.3 mos – NE] in MZL, 11.1 mos [8.3-15.6 mos] in FL
  • Median PFS: NR [12.1 mos – NE] in MZL, 10.6 mos [7.2-13.7 mos] in FL
Safety:
  • Grade 3-4 AEs: Diarrhea (10%), neutropenia (12%), increased ALT (7%)

Blood (2020) 136 (Supplement 1): 34–35

Zinzani PL, et al. Umbralisib, the Once Daily Dual Inhibitor of PI3Kδ and Casein Kinase-1ε Demonstrates Clinical Activity in Patients with Relapsed or Refractory Indolent Non-Hodgkin Lymphoma: Results from the Phase 2 Global Unity-NHL Trial

https://doi.org/10.1182/blood-2020-134851

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