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New Indication: Adjuvant nivolumab for esophageal / GE junction cancer

New Indication: Adjuvant nivolumab for esophageal / GE junction cancer
  • Randomized, double-blind phase III trial (CheckMate 577)
  • Esophageal or GE junction cancer (adeno or SCC) pts who received neoadjuvant chemoRT => undergone R0 resection during which pathological residual disease was found
  • Adjuvant nivolumab vs. placebo x 1 year or until disease progression
  • Median DFS: 22.4 vs. 11.0 mos (HR: 0.69 [0.56-0.86])
  • Median distant metastasis-free survival: 28.3 vs. 17.6 mos (HR: 0.74 [0.60-0.92])
  • Grade >=3 AEs: fatigue (1% vs. <1%), diarrhea (<1% vs. <1%), rash (<1% vs. <1%)

N Engl J Med 2021;384:1191-203.

Kelly RJ, et al. Adjuvant Nivolumab in Resected Esophageal or Gastroesophageal Junction Cancer

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Altai Chemo Planner employs Altai Protocol Library that includes over 1000 chemotherapy protocols for both Hematology and Oncology. You can find major guidelines' protocols, parenteral, and oral, in the library. Altai Protocol Library is frequently and regularly updated.

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