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Kütüphanede Ara Ara
Altai Protocol Library

New Indication: Avapritinib for Advanced Systemic Mastocytosis

New Indication: Avapritinib for Advanced Systemic Mastocytosis
Study:
  • Phase II study with 2 cohorts (PATHFINDER)
  • Advanced systemic mastocytosis
  • Avapritinib 200 mg PO daily (N=32, interim analysis)
Efficacy:
  • CRR: 19%
  • ORR: 75%
  • 93% of pts achieved >=50% reduction in serum tryptase
  • 66% of pts achieved >=35% reduction in spleen volume
Safety:
  • Grade >= 3 AEs: Neutropenia (24%), thrombocytopenia (16%), anemia (16%), edema (3%)

AACR Annual Meeting 2021

DeAngelo DJ, et al. PATHFINDER: Interim Analysis of Avapritinib in Patients with Advanced Systemic Mastocytosis (AdvSM)

https://www.blueprintmedicines.com/wp-content/uploads/2021/04/Blueprint-Medicines-AACR-2021-Avapritinib-Advanced-SM-PATHFINDER-Presentation.pdf

Altai Chemo Planner

Quickly Prepare Accurate Chemotherapy Orders

Altai Chemo Planner employs Altai Protocol Library that includes over 1000 chemotherapy protocols for both Hematology and Oncology. You can find major guidelines' protocols, parenteral, and oral, in the library. Altai Protocol Library is frequently and regularly updated.

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