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New Indication: Avelumab as Second-Line Treatment in Patients with Metastatic Colorectal Cancer and Microsatellite Instability

New Indication: Avelumab as Second-Line Treatment in Patients with Metastatic Colorectal Cancer and Microsatellite Instability
Study:
  • A Phase II, Randomized, Open-label, multicenter trial
  • Progression under first-line treatment (except for immunotherapy) of dMMR/MSI metastatic colorectal cancer
  • Avelumab (n=65) vs SOC (n=67)
Efficacy:
  • mOS: 25.8 vs. 23.4 mos, p=0.790
  • mPFS: 4.1 vs. 6.2 mos, p=0.030
  • 12 mos PFS: 31.2% vs 19.4%
  • 18 mos PFS: 27.4% vs. 9.1%
  • ORR: 29.5% vs 26.2%
Safety:
  • Grade≥3: Liver enzyme increased (7.9% vs.1.6%), diarrhea (4.8% vs.7.8%), neutropenia (0 vs.18.8%), hypertension (1% vs 10.9%).

JAMA Oncol, AUG, 2023

Taïeb J, Bouche O, André T, et al. Avelumab vs Standard Second-Line Chemotherapy in Patients With Metastatic Colorectal Cancer and Microsatellite Instability: A Randomized Clinical Trial

http://doi.org/10.1001/jamaoncol.2023.2761

Reviewed by Elvin CHALABİYEV, MD on AUG 10, 2023

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