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New Indication: Axitinib for unresectable recurrent or metastatic head and neck cancer

New Indication: Axitinib for unresectable recurrent or metastatic head and neck cancer
Single-arm phase 2 trial
Unresectable recurrent or metastatic (R/M) head and neck squamous cell carcinoma (n=29)
61% had at least 1 previous systemic treatment
Results: Median OS: 9.8 mos. 6-month OS: 70%
ORR: 42% => ORR higher in those with PI3K pathway alterations (75% vs. 17%)

Cancer. Online first 2020 Oct 20.
Swiecicki PL, et al. Efficacy of axitinib in metastatic head and neck cancer with novel radiographic response criteria. Cancer.
https://doi.org/10.1002/cncr.33226

Reviewed by Ulas Darda Bayraktar, MD on Nov 2, 2020

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