1. Home /
    2. Altai Protocol Library /
  2. New Indication: Cabozantinib plus atezolizumab versus sorafenib for advanced hepatocellular carcinoma (COSMIC-312)

Altai Protocol Library

1041 protocols and counting

All protocols with references and links

All protocols reviewed by a Medical Oncologist/Hematologist

All protocols in major guidelines included

Ability to create your own protocols

Kütüphanede Ara Ara
Altai Protocol Library

New Indication: Cabozantinib plus atezolizumab versus sorafenib for advanced hepatocellular carcinoma (COSMIC-312)

New Indication: Cabozantinib plus atezolizumab versus sorafenib for advanced hepatocellular carcinoma (COSMIC-312)
Study:
  • Open-label, randomised, phase 3 trial
  • Previously untreated advanced hepatocellular carcinoma
  • Cabozantinib 40 mg plus atezolizumab 1200 mg IV every 3 weeks (N:432), sorafenib 400 mg twice Daily (n:217), or cabozantinib 60 mg orally once daily (188)
Efficacy:
  • mPFS: 6·8 months (99% CI 5·6–8·3) in the combination treatment group vs 4·2 months (2·8–7·0) in the sorafenib group (hazard ratio [HR] 0·63, 99% CI 0·44–0·91, p=0·0012)
  • mOS: 15·4 months in the combination treatment group vs 15·5 months in the sorafenib group (HR 0·90, 96% CI 0·69–1·18; p=0·44).
Safety:
  • Any grade TEAE: 428 (>99%) of 429 patients vs 205 (99%) of 207 patients vs 187 (99%) of 188
  • Grade 3-4 AEs: 273 (64%), 95 (46%), and 113 (60%); ALT increase 9%, 3%, 6%; hypertension 9%, 8%,12%
  • Any grade treatment-emergent haemorrhagic events 71 (17%) vs 29 (14%) vs 28 (15%)

Lancet Oncol. 2022 Aug;23(8):995-1008.

Kelley RK, Rimassa L, Cheng AL, et al. Cabozantinib plus atezolizumab versus sorafenib for advanced hepatocellular carcinoma (COSMIC-312): a multicentre, open-label, randomised, phase 3 trial.

https://doi.org/10.1016/s1470-2045(22)00326-6

Reviewed by Hasan Çağrı Yıldırım, MD on Aug 16, 2022

Altai Chemo Planner

Quickly Prepare Accurate Chemotherapy Orders

Altai Chemo Planner employs Altai Protocol Library that includes over 1000 chemotherapy protocols for both Hematology and Oncology. You can find major guidelines' protocols, parenteral, and oral, in the library. Altai Protocol Library is frequently and regularly updated.

Learn More