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New Indication: Dabrafenib + trametinib for bRAF V600E mutant glioma

New Indication: Dabrafenib + trametinib for bRAF V600E mutant glioma
  • Open-label, single-arm, phase 2, basket trial
  • BRAFV600E mutation-positive high- low-grade glioma
  • Prior radiotherapy and chemotherapy or chemoradiotherapy for high grade glioma
  • Dabrafenib 150 mg twice daily plus trametinib 2 mg once daily
  • High grade glioma; OR: 15/45 patients, CR:3 PR:12
  • Low-grade glioma; OR:9/13 patients, CR:1, PR:6, minor response:2
  • Grade >=3 AEs: 53%
  • Fatigue: 9%, headache: 5%, neutropenia: 5%,

Lancet Oncol. 2022; 23(1):53-64.

Wen PY, et al. Dabrafenib plus trametinib in patients with BRAFV600E-mutant low-grade and high-grade glioma (ROAR): a multicentre, open-label, single-arm, phase 2, basket trial

Reviewed by Hasan Cagri Yildirim, MD on Sep 30, 2021

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