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New Indication: Dostarlimab for dMMR solid cancers

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Altai Protocol Library October 4, 2021

New Indication: Dostarlimab for dMMR solid cancers

New Indication: Dostarlimab for dMMR solid cancers
Study:	Cohort F of phase I GARNET trial Progressed following systemic therapy and dMMR by IHC (mostly GI tract origin) Dostarlimab 500 mg q21 x 4 => 1000 mg q42 (N=106)
Efficacy:	ORR: 38.7% [29.4% – 48.6%] Probability of maintaining response @ 12 mos: 91.0% 56% of responders with ccRCC had DoR over one year
Safety:	Grade >= 3 AEs reported in 8.3% of pts. Most common was increased lipase (1.4%)
J Clin Oncol 2021;39: suppl 9. Andre T, et al. Safety and efficacy of anti–PD-1 antibody dostarlimab in patients (pts) with mismatch repair-deficient (dMMR) solid cancers: Results from GARNET study https://doi.org/10.1200/JCO.2021.39.3_suppl.9

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