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New Indication: FOLFOX for second-line advanced biliary tract cancer

New Indication: FOLFOX for second-line advanced biliary tract cancer
Study:
  • Phase III, open-label, randomized trial (ABC-06)
  • Locally advanced or metastatic biliary tract cancer with progression to CISplatin – gemcitabine
  • FOLFOX-6 vs. active symptom control
Efficacy:
  • FOLFOX group => ORR: 5% and PFS @6 mos: 32%
  • Median OS: 6.2 mos vs. 5.3 mos (HR: 0.69 [0.50-0.97])
Safety:
  • Grade >=3 AEs: fatigue (19% vs. 7%), infection (18% vs. 6%), biliary events (19% vs. 20%), neutropenia (12% vs. 1%)
  •  

Lancet Oncol 2021; 22: 690–701

Lamarca A, et al. Second-line FOLFOX chemotherapy versus active symptom control for advanced biliary tract cancer (ABC-06): a phase 3, open-label, randomised, controlled trial

https://doi.org/10.1016/S1470-2045(21)00027-9

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