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New Indication: Gemcitabine and Cisplatin as Neoadjuvant Chemotherapy for Patients with High-Grade Upper Tract Urothelial Carcinoma

New Indication: Gemcitabine and Cisplatin as Neoadjuvant Chemotherapy for Patients with High-Grade Upper Tract Urothelial Carcinoma
Study:
  • Multicenter, single-arm, phase II trial
  • Localized high-grade UTUC or radiographically visible invasive disease
  • Four cycles of split-dose GC (n=57)
Efficacy:
  • Pathologic response rate: 63% (37 of 57 pts)
  • Complete response rate: 19% (11 of 57 pts)
  • 2-year PFS: 89% [81-98], 5-year PFS: 72% [59-87]
  • 2-year OS: 93% [86-100], 5-year OS: 79% [67-94]
Safety:
  • Grade≥3 AEs: Neutropenia (33%), febrile neutropenia (7.0%), thrombocytopenia (7.0%), creatinine increased (5.3%)

J Clin Oncol 2023: 05 JAN.

Coleman A.J et al. ¨ Multicenter Phase II Clinical Trial of Gemcitabine and Cisplatin as Neoadjuvant Chemotherapy for Patients With High-Grade Upper Tract Urothelial Carcinoma

http://doi.org/10.1200/JCO.22.00763

Reviewed by Elvin CHALABİYEV, MD on FEB 24, 2023

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