1. Home /
    2. Altai Protocol Library /
  2. New Indication: Larotrectinib for TRK + Sarcomas

Altai Protocol Library

1041 protocols and counting

All protocols with references and links

All protocols reviewed by a Medical Oncologist/Hematologist

All protocols in major guidelines included

Ability to create your own protocols

Search Library Posts Search
Altai Protocol Library

New Indication: Larotrectinib for TRK + Sarcomas

New Indication: Larotrectinib for TRK + Sarcomas
Study:
  • Analysis of three separate clinical trials
  • Adult pts with sarcomas harboring NTRK gene fusions
  • N = 25 => 19 soft tissue sarcoma (STS) – 4 GIST – 2 bone sarcoma (BOS)
Efficacy:
  • ORR: 72% => 68% (STS), 100% (GIST), 50% (BOS)
  • CR: 16% => 16% (STS), 25% (GIST), none (BOS)
  • Median DoR: Not-reached
  • Median PFS: 28.3 mos [6.8 – NE]
Safety:
  • Grade 3 AEs: Abdominal pain (1), fatigue (1), anemia (2), anxiety (1), UTI (1)

Connective Tissue Oncology Society (CTOS) 2020 Virtual Meeting

Kummar S, et al. Larotrectinib efficacy and safety in adult patients with TRK fusion sarcomas.

CTOS poster

Altai Chemo Planner

Quickly Prepare Accurate Chemotherapy Orders

Altai Chemo Planner employs Altai Protocol Library that includes over 1000 chemotherapy protocols for both Hematology and Oncology. You can find major guidelines' protocols, parenteral, and oral, in the library. Altai Protocol Library is frequently and regularly updated.

Learn More