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New Indication: Larotrectinib for TRK + Sarcomas

New Indication: Larotrectinib for TRK + Sarcomas

Analysis of three separate clinical trials
Adult pts with sarcomas harboring NTRK gene fusions
N = 25 => 19 soft tissue sarcoma (STS) – 4 GIST – 2 bone sarcoma (BOS)
ORR: 72% => 68% (STS), 100% (GIST), 50% (BOS)
CR: 16% => 16% (STS), 25% (GIST), none (BOS)
Median DoR: Not-reached
Median PFS: 28.3 mos [6.8 – NE]
Grade 3 AEs: Abdominal pain (1), fatigue (1), anemia (2), anxiety (1), UTI (1)

Connective Tissue Oncology Society (CTOS) 2020 Virtual Meeting
Kummar S, et al. Larotrectinib efficacy and safety in adult patients with TRK fusion sarcomas.
CTOS poster

Reviewed by Ulas Darda Bayraktar, MD on Jan 12, 2020

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