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New Indication: Larotrectinib for TRK + Sarcomas - Altai Oncology
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New Indication: Larotrectinib for TRK + Sarcomas

New Indication: Larotrectinib for TRK + Sarcomas
Study:
  • Analysis of three separate clinical trials
  • Adult pts with sarcomas harboring NTRK gene fusions
  • N = 25 => 19 soft tissue sarcoma (STS) – 4 GIST – 2 bone sarcoma (BOS)
Efficacy:
  • ORR: 72% => 68% (STS), 100% (GIST), 50% (BOS)
  • CR: 16% => 16% (STS), 25% (GIST), none (BOS)
  • Median DoR: Not-reached
  • Median PFS: 28.3 mos [6.8 – NE]
Safety:
  • Grade 3 AEs: Abdominal pain (1), fatigue (1), anemia (2), anxiety (1), UTI (1)

Connective Tissue Oncology Society (CTOS) 2020 Virtual Meeting

Kummar S, et al. Larotrectinib efficacy and safety in adult patients with TRK fusion sarcomas.

CTOS poster

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