Altai Protocol Library

1041 protocols and counting

All protocols with references and links

All protocols reviewed by a Medical Oncologist/Hematologist

All protocols in major guidelines included

Ability to create your own protocols

Kütüphanede Ara Ara

New Indication: Lenvatinib + Pembrolizumab for advanced renal cell carcinoma

New Indication: Lenvatinib + Pembrolizumab for advanced renal cell carcinoma
  • Randomized phase III trial (CLEAR)
  • Advanced renal cell carcinoma with no previous therapy
  • Lenvatinib (LEN) + pembrolizumab (PEM) (n=355) vs. lenvatinib + everolimus (EVE) (n=357) vs. sunitinib (SUN) (n=357)
  • ORR: 71.0% vs. 53.5% vs. 36.1% (RR btw LEN+PEM vs. SUN: 1.97 [1.69-2.29])
  • CR: 16.1% vs. 9.8% vs. 4.2%
  • Median PFS: 23.9 mos vs. 14.7 mos vs. 9.2 mos (HR btw LEN+PEM vs. SUN: 0.39 [0.32-0.49])
  • Median OS: NR for all groups. Significantly longer in LEN+PEM vs. SUN (HR: 0.66 [0.49-0.88])
  • Grade 3-4 AEs: Diarrhea (10% vs. 12% vs. 5%), hypertension (28% vs. 23% vs. 19%), hypothyroidism (1.4% vs. 0.6% vs. 0), proteinuria (8% vs. 8% vs. 3%), PPE (4% vs. 3% vs. 4%)

N Engl J Med. Published online on Feb 13, 2021

Motzer R, et al. Lenvatinib plus Pembrolizumab or Everolimus for Advanced Renal Cell Carcinoma

Altai Chemo Planner

Quickly Prepare Accurate Chemotherapy Orders

Altai Chemo Planner employs Altai Protocol Library that includes over 1000 chemotherapy protocols for both Hematology and Oncology. You can find major guidelines' protocols, parenteral, and oral, in the library. Altai Protocol Library is frequently and regularly updated.

Learn More