Altai Protocol Library

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New Indication: Lenvatinib + Pembrolizumab for advanced renal cell carcinoma

New Indication: Lenvatinib + Pembrolizumab for advanced renal cell carcinoma
Study:
  • Randomized phase III trial (CLEAR)
  • Advanced renal cell carcinoma with no previous therapy
  • Lenvatinib (LEN) + pembrolizumab (PEM) (n=355) vs. lenvatinib + everolimus (EVE) (n=357) vs. sunitinib (SUN) (n=357)
Efficacy:
  • ORR: 71.0% vs. 53.5% vs. 36.1% (RR btw LEN+PEM vs. SUN: 1.97 [1.69-2.29])
  • CR: 16.1% vs. 9.8% vs. 4.2%
  • Median PFS: 23.9 mos vs. 14.7 mos vs. 9.2 mos (HR btw LEN+PEM vs. SUN: 0.39 [0.32-0.49])
  • Median OS: NR for all groups. Significantly longer in LEN+PEM vs. SUN (HR: 0.66 [0.49-0.88])
Safety:
  • Grade 3-4 AEs: Diarrhea (10% vs. 12% vs. 5%), hypertension (28% vs. 23% vs. 19%), hypothyroidism (1.4% vs. 0.6% vs. 0), proteinuria (8% vs. 8% vs. 3%), PPE (4% vs. 3% vs. 4%)

N Engl J Med. Published online on Feb 13, 2021

Motzer R, et al. Lenvatinib plus Pembrolizumab or Everolimus for Advanced Renal Cell Carcinoma

https://doi.org/10.1056/NEJMoa2035716

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Altai Chemo Planner employs Altai Protocol Library that includes over 1000 chemotherapy protocols for both Hematology and Oncology. You can find major guidelines' protocols, parenteral, and oral, in the library. Altai Protocol Library is frequently and regularly updated.

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