1. Home /
    2. Altai Protocol Library /
  2. New Indication: Liposomal Irinotecan Plus Fluorouracil and Leucovorin for Patients with Previously Treated Metastatic Biliary Tract Cancer

Altai Protocol Library

1041 protocols and counting

All protocols with references and links

All protocols reviewed by a Medical Oncologist/Hematologist

All protocols in major guidelines included

Ability to create your own protocols

Search Library Posts Search
Altai Protocol Library

New Indication: Liposomal Irinotecan Plus Fluorouracil and Leucovorin for Patients with Previously Treated Metastatic Biliary Tract Cancer

New Indication: Liposomal Irinotecan Plus Fluorouracil and Leucovorin for Patients with Previously Treated Metastatic Biliary Tract Cancer
Study:
  • Multicenter, randomized, open-label phase 2b trial (NIFTY)
  • Advanced biliary tract cancer whose disease progressed while receiving first-line gemcitabine plus cisplatin
  • nal-IRI + FU+LV (n=88) vs. FU+LV (n=86)
Efficacy:
  • mPFS: 4.2 vs. 1.7 mos, p=0.004
Safety:
  • Grade≥3 AEs: neutropenia (24% vs. 1%), fatigue (11 vs.3%)

JAMA Oncol, 2023, 23 Mar

Hyung Jaewon et al. Treatment With Liposomal Irinotecan Plus Fluorouracil and Leucovorin for Patients With Previously Treated Metastatic Biliary Tract Cancer The Phase 2b NIFTY Randomized Clinical Trial

http://doi.org/10.1001/jamaoncol.2023.0016

Reviewed by Elvin CHALABİYEV, MD on APR 17, 2023

Altai Chemo Planner

Quickly Prepare Accurate Chemotherapy Orders

Altai Chemo Planner employs Altai Protocol Library that includes over 1000 chemotherapy protocols for both Hematology and Oncology. You can find major guidelines' protocols, parenteral, and oral, in the library. Altai Protocol Library is frequently and regularly updated.

Learn More