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New Indication: Neoadjuvant Cemiplimab for Stage II to IV Cutaneous Squamous-Cell Carcinoma

New Indication: Neoadjuvant Cemiplimab for Stage II to IV Cutaneous Squamous-Cell Carcinoma
Study:
  • Phase 2, confirmatory, multicenter, nonrandomized study
  • Resectable stage II, III, or IV (M0) cutaneous squamous-cell carcinoma
  • Cemiplimab 350 mg/21 day (four doses) before surgery (N:79)
Efficacy:
  • pCR: 40 (51%)
  • Pathological major response: 10 (13%)
  • ORR (imaging): 68%
Safety:
  • Any grade AEs: 87%, serious event: 16%, fatigue:30%, diarrhea:14%, nausea:14%
  • Any grade ≥3 AEs: 18%, serious event: 13%, hyponatremia:3%

N Engl J Med. 2022 Sep 12.

Gross ND, Miller DM, Khushalani NI, et al. Neoadjuvant Cemiplimab for Stage II to IV Cutaneous Squamous-Cell Carcinoma

https://doi.org/10.1056/nejmoa2209813

Reviewed by Hasan Çağrı Yıldırım, MD on Sep 27, 2022

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Altai Chemo Planner employs Altai Protocol Library that includes over 1000 chemotherapy protocols for both Hematology and Oncology. You can find major guidelines' protocols, parenteral, and oral, in the library. Altai Protocol Library is frequently and regularly updated.

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