1. Home /
    2. Altai Protocol Library /
  2. New Indication: Neoadjuvant FOLFIRINOX for locally advanced rectal cancer

Altai Protocol Library

1041 protocols and counting

All protocols with references and links

All protocols reviewed by a Medical Oncologist/Hematologist

All protocols in major guidelines included

Ability to create your own protocols

Kütüphanede Ara Ara
Altai Protocol Library

New Indication: Neoadjuvant FOLFIRINOX for locally advanced rectal cancer

New Indication: Neoadjuvant FOLFIRINOX for locally advanced rectal cancer
Study:
  • Randomized, open-label phase III (UNICANCER-PRODIGE 23)
  • Newly diagnosed cT3/T4M0 rectal adenoCa
  • Arm A: 6 cycles of FOLFIRINOX => Chemoradiotherapy (50 Gy with capecitabine) => Surgery => Adjuvant chemo (mFOLFOX6 or capecitabine) x 3 mos
  • Arm B: Chemoradiotherapy => Surgery => Adjuvant chemo x 6 mos
Efficacy:
  • Metastatic progression @ pre-op CT: 1% vs. 5%
  • Proceeded to surgery: 92% vs. 95%
  • Two patients who refused surgery in Arm A are in CR @ 5 yr follow-up
  • Definitive colostomy: 14% vs. 15%
  • R0 resection: 95% vs. 94%
  • Pathological CR: 28% vs. 12% (p <0.0001)
  • Post-op morbidity rates similar
  • DFS @ 3 yrs: 76% vs. 69% (HR: 0.69 [0.49-0.97])
  • OS @ 3 yrs: 91% vs. 88%
Safety:
  • Grade >=3 AEs during neoadj FOLFIRINOX: Neutropenia (12%), febrile neutropenia (1%), thrombocytopenia (1%), anemia (1%), fatigue (7%), diarrhea (9%), vomiting (4%), neuropathy (2%), thromboembolic event (3%)

Lancet Oncol 2021; 22: 702–15

Conroy T, et al. Neoadjuvant chemotherapy with FOLFIRINOX and preoperative chemoradiotherapy for patients with locally advanced rectal cancer (UNICANCER-PRODIGE 23): a multicentre, randomised, open-label, phase 3 trial

https://doi.org/10.1016/S1470-2045(21)00079-6

Altai Chemo Planner

Quickly Prepare Accurate Chemotherapy Orders

Altai Chemo Planner employs Altai Protocol Library that includes over 1000 chemotherapy protocols for both Hematology and Oncology. You can find major guidelines' protocols, parenteral, and oral, in the library. Altai Protocol Library is frequently and regularly updated.

Learn More