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New Indication: Neoadjuvant Nivolumab plus Chemotherapy in Resectable Lung Cancer

New Indication: Neoadjuvant Nivolumab plus Chemotherapy in Resectable Lung Cancer
Study:
  • Open-label, phase 3 trial
  • Stage IB to IIIA resectable NSCLC
  • Three cycles neoadjuvant treatment
  • Nivolumab plus platinum-based chemotherapy (N:176) or platinum-based chemotherapy (N:176)
Efficacy:
  • mEFS: 31.6 m vs 20.8 m (HR:0.63; 97.38% CI, 0.43 to 0.91; P=0.005)
  • Pathological CR 24.0% vs 2.2% (OR:13.94; 99% CI, 3.49 to 55.75; P<0.001)
  • mOS:NR vs NR (HR: 0.57; 99.67% CI, 0.30 to 1.07; P=0.008)
Safety:
  • Grade >= 3 AEs: 33.5% vs 36.9%
  • Grade >=3 AEs neutropenia:8.5% vs 11.9%
  • Discontinuation of treatment 10.2% vs 9.7%

N Engl J Med 2022 May 26;386(21):1973-1985.

Forde, Patrick M et al. “Neoadjuvant Nivolumab plus Chemotherapy in Resectable Lung Cancer.”

https://doi.org/10.1056/nejmoa2202170

Reviewed by Hasan Çağrı Yıldırım, MD on Jul 05, 2022

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