Altai Protocol Library

1041 protocols and counting

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Altai Protocol Library February 8, 2021

New Indication: Nivolumab + ipilimumab for first-line unresectable malignant pleural mesothelioma

New Indication: Nivolumab + ipilimumab for first-line unresectable malignant pleural mesothelioma
Study:	Open-label, randomized phase III trial (CheckMate 743) Previously untreated unresectable MPM Nivolumab + ipilimumab x 2 yrs (n=303) vs. platinum + pemetrexed x 6 cycles (n=302)
Efficacy:	ORR: 40% vs. 43% Median DoR: 11.0 mos [8.1-16.5 mos] vs. 6.7 mos [5.3-7.1 mos] Median PFS: 6.8 mos vs. 7.2 mos (HR: 1.00 [0.82-1.21]) Median OS: 18.1 mos vs. 14.1 mos [HR: 0.74 [0.60-0.91]) Median OS for PD-L1 <1%: 17.3 mos vs. 16.5 mos
Safety:	Grade 3-4 AEs: Diarrhea (3% vs. 1%), anemia (1% vs. 11%), increased lipase (5% vs. 1%), neutropenia (1% vs. 15%)
Lancet 2021; 397: 375–86. Pfeiffer P, et al. First-line nivolumab plus ipilimumab in unresectable malignant pleural mesothelioma (CheckMate 743): a multicentre, randomised, open-label, phase 3 trial https://doi.org/10.1016/S0140-6736(20)32714-8

Altai Chemo Planner

Quickly Prepare Accurate Chemotherapy Orders

Altai Chemo Planner employs Altai Protocol Library that includes over 1000 chemotherapy protocols for both Hematology and Oncology. You can find major guidelines' protocols, parenteral, and oral, in the library. Altai Protocol Library is frequently and regularly updated.