Altai Protocol Library

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New Indication: Osimertinib as adjuvant therapy for EGFR-mutated NSCLC

New Indication: Osimertinib as adjuvant therapy for EGFR-mutated NSCLC

Double-blind, phase 3 trial (ADAURA)
Completely resected, non-squamous, stage IB, II, or IIIA; EGFR mutation-positive
Osimertinib (n=339) vs. placebo (n=343)
DFS @ 2 yrs: 89% vs. 52% (HR: 0.20 [0.14-0.30])
CNS-disease free survival @ 2 yrs: 98% vs. 85% (HR: 0.18 [0.10-0.33])
Grade 3-4 AEs: Diarrhea (2%), stomatitis (2%), paronychia, decreased appetite

N Engl J Med 2020; 383:1711-1723
Yi-Long W, et al. Osimertinib in Resected EGFR-Mutated Non–Small-Cell Lung Cancer
https://doi.org/10.1056/NEJMoa2027071

Reviewed by Ulas Darda Bayraktar, MD on Dec 22, 2020

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Altai Chemo Planner employs Altai Protocol Library that includes over 1000 chemotherapy protocols for both Hematology and Oncology. You can find major guidelines' protocols, parenteral, and oral, in the library. Altai Protocol Library is frequently and regularly updated.

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