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New Indication: Osimertinib as adjuvant therapy for EGFR-mutated NSCLC

New Indication: Osimertinib as adjuvant therapy for EGFR-mutated NSCLC
Study:
  • Double-blind, phase 3 trial (ADAURA)
  • Completely resected, non-squamous, stage IB, II, or IIIA; EGFR mutation-positive
  • Osimertinib (n=339) vs. placebo (n=343)
Efficacy:
  • DFS @ 2 yrs: 89% vs. 52% (HR: 0.20 [0.14-0.30])
  • CNS-disease free survival @ 2 yrs: 98% vs. 85% (HR: 0.18 [0.10-0.33])
Safety:
  • Grade 3-4 AEs: Diarrhea (2%), stomatitis (2%), paronychia, decreased appetite

N Engl J Med 2020; 383:1711-1723

Yi-Long W, et al. Osimertinib in Resected EGFR-Mutated Non–Small-Cell Lung Cancer

https://doi.org/10.1056/NEJMoa2027071

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Altai Chemo Planner employs Altai Protocol Library that includes over 1000 chemotherapy protocols for both Hematology and Oncology. You can find major guidelines' protocols, parenteral, and oral, in the library. Altai Protocol Library is frequently and regularly updated.

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