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New Indication: Pembrolizumab Added to Ifosfamide, Carboplatin, and Etoposide Chemotherapy for Relapsed or Refractory Classic Hodgkin Lymphoma

New Indication: Pembrolizumab Added to Ifosfamide, Carboplatin, and Etoposide Chemotherapy for Relapsed or Refractory Classic Hodgkin Lymphoma
Study:
  • Multicenter, non-randomized, phase 2trial
  • Relapsed or refractory classic Hodgkin lymphoma
  • Pembrolizumab + ICE (n=37)
Efficacy:
  • CRR: 86.5% [32 of 37 pts]
  • ORR: 97.3% [36 of 37 pts]
  • 2-year PFS: 87.2% [77.5-98.3]
  • 2-year OS: 95.1% [88.8%-100%]
Safety:
  • Grade≥3AEs: cytopenias, elevated AST/ALT, hyponatremia, hypophosphatemia, and fatigue.

JAMA Oncol, 2023, 16 MAR

Bryan J. Locke et al. Pembrolizumab Added to Ifosfamide, Carboplatin, and Etoposide Chemotherapy for Relapsed or Refractory Classic Hodgkin Lymphoma A Multi-institutional Phase 2 Investigator-Initiated Nonrandomized Clinical Trial

http://doi.org/10.1001/jamaoncol.2022.7975

Reviewed by Elvin CHALABİYEV, MD on APR 17, 2023

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