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New Indication: Pembrolizumab plus Chemotherapy in Advanced Endometrial Cancer

New Indication: Pembrolizumab plus Chemotherapy in Advanced Endometrial Cancer
Study:
  • Phase III, randomized, double-blind, placebo-controlled
  • Advanced-stage, metastatic, or recurrent endometrial cancer of any histologic subtype except for carcinosarcoma
  • Pembrolizumab + Chemotherapy (n=365) vs. Chemotherapy (n=548)
Efficacy:
    dMMR cohort
  • mPFS: NR vs. 7.6 mos, p<0.001
  • 12 mos PFS: 74% vs. 38%, p<0.001
    • pMMR cohort
  • •mPFS: 13.1 vs. 8.7 mos, p<0.001
Safety:
  • Any grade: fatigue (71.6% vs 55.7%), peripheral sensory neuropathy (65% vs.62%), anemia (57.8% vs. 54.7%), nausea (50.5% vs. 41.5%)
  • Grade≥3 AEs: Anemia (19.3% vs. 10.4%), neutropenia (11.9% vs. 17.0%)

N Engl J Med 2023; 27 Mar

Eskander N. Ramez et al. Pembrolizumab plus Chemotherapy in Advanced Endometrial Cancer

http://doi.org/10.1056/NEJMoa2302312

Reviewed by Elvin CHALABİYEV, MD on APR 17, 2023

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