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New İndication: Perioperative Nivolumab and Chemotherapy in Stage III Non–Small-Cell Lung Cancer

New İndication: Perioperative Nivolumab and Chemotherapy in Stage III Non–Small-Cell Lung Cancer
Study:
  • A Phase II , Randomized, Open-label , multicenter trial
  • Resectable, stage IIIA or IIIB NSCLC
  • Arm A: Nivolumab + Carboplatin + PaclitaxelS->Nivolumab (n=57) Arm B: Carboplatin + Paclitaxel S->PBO (n=29)
Efficacy:
  • 24 mos PFS: 67.2% vs 40.9%
  • 24 mos OS: 85.0% vs. 63.6%
  • mPR: 53.0% vs 14.0%
  • PcR: 37.0% vs. 7.0%
Safety:
  • Grade≥3: febrile neutropenia (7% vs.0%), fatigue (4% vs.3%), diarrhea (4% vs.0)

NEJM JUN 28, 2023

Provencio N et al. Perioperative Nivolumab and Chemotherapy in Stage III Non–Small-Cell Lung Cancer

http://doi.org/10.1056/NEJMoa2215530

Reviewed by Elvin CHALABİYEV, MD on JUL 10, 2023

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