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New Indication: Pralsetinib for advanced RET-mutated medullary thyroid cancer

New Indication: Pralsetinib for advanced RET-mutated medullary thyroid cancer

Phase I/II, single arm (ARROW trial)
Advanced RET mutation-positive medullary thyroid cancer (MTC, n= 79). Previously treated with cabozantinib or vandetanib or both (n=55)
ORR: 65% (overall, 53%-75%), 60% (previously treated, 46% – 74%)
18-mo PFS: 71% (previously treated, 58% – 85%)
Responses occurred regardless of RET mutation genotype (somatic or germline)
Grade 3-4 AEs: Neutropenia (16%), hypertension (14%), hypophosphatemia (11%), pneumonia (8%), interstitial lung disease (3%)

Annals of Oncology (2020) 31 (suppl_4)

Hu M, et al. Results from the registrational phase I/II ARROW trial of pralsetinib (BLU-667) in patients (pts) with advanced RET mutation-positive medullary thyroid cancer (RET+ MTC)
https://oncologypro.esmo.org/meeting-resources/esmo-virtual-congress-2020/results-from-the-registrational-phase-i-ii-arrow-trial-of-pralsetinib-blu-667-in-patients-pts-with-advanced-ret-mutation-positive-medullary-thy

Reviewed by Ulas Darda Bayraktar, MD on Dec 7, 2020

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