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New Indication: Rucaparib in Metastatic Castration-Resistant Prostate Cancer (mCRPC)

New Indication: Rucaparib in Metastatic Castration-Resistant Prostate Cancer (mCRPC)
Study:
  • Randomized, controlled, phase 3 trial (TRITON-3)
  • Metastatic, castration-resistant prostate cancer with a BRCA1, BRCA2, or ATM alteration and who had disease progression after treatment with a second-generation androgen-receptor pathway inhibitor (ARPI)
  • Rucaparib (n=270) vs. SOC (n=135)
Efficacy:
  • In BRCA1/2 mutant subgroup: mrPFS: 11.2 vs. 6.4 mos, p<0.001
  • In ITT group: mrPFS: 10.2 vs. 6.4 mos, p=<0.001
Safety:
  • Any grade: fatigue (61.% vs. 63%), nausea (50% vs 19%), anemia (47% vs 18%), diarrhea (31% vs. 28%)
  • Grade≥3 AEs: anemia (24% vs. 1%), fatigue (7% vs. 9%).

N Engl J Med 2023; 388:719-732

Fizazi K. et al. Rucaparib or Physician’s Choice in Metastatic Prostate Cancer

http://doi.org/10.1056/NEJMoa2214676

Reviewed by Elvin CHALABİYEV, MD on APR 17, 2023

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