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New Indication: Rucaparib in Metastatic Castration-Resistant Prostate Cancer (mCRPC)

New Indication: Rucaparib in Metastatic Castration-Resistant Prostate Cancer (mCRPC)
  • Randomized, controlled, phase 3 trial (TRITON-3)
  • Metastatic, castration-resistant prostate cancer with a BRCA1, BRCA2, or ATM alteration and who had disease progression after treatment with a second-generation androgen-receptor pathway inhibitor (ARPI)
  • Rucaparib (n=270) vs. SOC (n=135)
  • In BRCA1/2 mutant subgroup: mrPFS: 11.2 vs. 6.4 mos, p<0.001
  • In ITT group: mrPFS: 10.2 vs. 6.4 mos, p=<0.001
  • Any grade: fatigue (61.% vs. 63%), nausea (50% vs 19%), anemia (47% vs 18%), diarrhea (31% vs. 28%)
  • Grade≥3 AEs: anemia (24% vs. 1%), fatigue (7% vs. 9%).

N Engl J Med 2023; 388:719-732

Fizazi K. et al. Rucaparib or Physician’s Choice in Metastatic Prostate Cancer

Reviewed by Elvin CHALABİYEV, MD on APR 17, 2023

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Altai Chemo Planner employs Altai Protocol Library that includes over 1000 chemotherapy protocols for both Hematology and Oncology. You can find major guidelines' protocols, parenteral, and oral, in the library. Altai Protocol Library is frequently and regularly updated.

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