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New Indication: Sacituzumab govitecan for advanced urothelial cancer

New Indication: Sacituzumab govitecan for advanced urothelial cancer
  • Open-label phase II trial (TROPHY-U-01). Cohort 1 results
  • Unresectable locally advanced or metastatic urothelial cancer progressed after CISplatin and checkpoint inhibitors
  • Sacituzumab govitecan 10 mg/kg on days 1,8 (21d) (N=113)
  • CR: 6%, ORR: 27%
  • Median DoR: 5.9 mos
  • Median PFS: 5.4 mos [3.5-6.9 mos]
  • Median OS: 10.5 mos [8.2-12.3 mos]
  • Grade >=3 AEs: neutropenia (35%), anemia (14%), febrile neutropenia (10%), diarrhea (10%)

Annals of Oncology (2020) 31 (suppl_4): S1142-S1215.

Loriot Y, et al. TROPHY-U-01 cohort 1 final results: A phase II study of sacituzumab govitecan (SG) in metastatic urothelial cancer (mUC) that has progressed after platinum (PLT) and checkpoint inhibitors (CPI)

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Altai Chemo Planner employs Altai Protocol Library that includes over 1000 chemotherapy protocols for both Hematology and Oncology. You can find major guidelines' protocols, parenteral, and oral, in the library. Altai Protocol Library is frequently and regularly updated.

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