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New indication: Subcutaneous Rituximab for the First-Line Treatment of Low–Tumor Burden Follicular Lymphoma

New indication: Subcutaneous Rituximab for the First-Line Treatment of Low–Tumor Burden Follicular Lymphoma
Study:
  • Randomized, open-label phase 3 trial (LYSA)
  • Previously untreated low-burden Follicular lymphoma
  • SOC (n=102) vs. Rituximab sc (n=100)
Efficacy:
  • CR: 36.3% vs. 59.0%, p=0.001
  • 4-year PFS: 41.2% vs.58.1%, p=0.008
  • 4-year OS:95.0 vs.96.7%, p=ns
Safety:
  • Grade≥3 AEs: Lymphopenia (3.0% in both arm), injection site reaction (3.0% in both arm)

J Clin Oncol APR 18, 2023

Cartron G et al. Randomized Phase III Trial Evaluating Subcutaneous Rituximab for the First-Line Treatment of Low–Tumor Burden Follicular Lymphoma: Results of a LYSA Study

http://doi.org/10.1200/JCO.22.02327

Reviewed by Elvin CHALABİYEV, MD on MAY 10, 2023

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