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Kütüphanede Ara Ara
Altai Protocol Library

New Indication: Trastuzumab deruxtecan for her2+ NSCLC

New Indication: Trastuzumab deruxtecan for her2+ NSCLC
Study:
  • Multicenter, international, phase 2 study
  • Metastatic HER2-mutant NSCLC (refractory to standard treatment)
  • Trastuzumab deruxtecan >= 6.4 mg per kilogram of body weight
Efficacy:
  • ORR: 55% (95% CI, 44 to 65)
  • Median DOR: 9.3 months (95% CI, 5.7 to 14.7)
  • Median PFS: 8.2 months (95% CI, 6.0 to 11.9)
  • Median OS:17.8 months (95% CI, 13.8 to 22.1).
Safety:
  • Grade >=3 AEs: 46%, neutropenia 19%
  • Drug-related interstitial lung disease: 26% => 2 death

N Engl J Med. 2022; 386:241-251

Li BT, et al. Trastuzumab Deruxtecan in HER2-Mutant Non–Small-Cell Lung Cancer

https://doi.org/10.1056/NEJMoa2112431

Reviewed by Hasan Cagri Yildirim, MD on Sep 30, 2021

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