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New Indication: Trastuzumab Deruxtecan in HER2-Low Advanced Breast Cancer

New Indication: Trastuzumab Deruxtecan in HER2-Low Advanced Breast Cancer
  • Randomized, two-group, open- label, phase 3 trial
  • HER2- low, unresectable or metastatic breast cancer
  • One or two previous lines of chemotherapy
  • Trastuzumab deruxtecan (N:373) or the physician’s choice of chemotherapy (N:184)
  • HER2 low disease: IHC 1+ or IHC 2+ and negative in situ hybridization.
  • mPFS: 9.9 m vs 5.1 m (HR:0.50; P<0.001)
  • mOS: 23.4 m vs 16.8 m (HR: 0.64; P=0.001)
  • Grade >= 3 AEs: 52.6% vs 67.4%
  • Drug related interstitial lung disease or pneumonitis: 12.1% for trastuzumab deruxtecan, 0.8% had grade 5 events.

N Engl J Med 2022 Jun 5. doi: 10.1056/NEJMoa2203690.

Modi, Shanu et al. “Trastuzumab Deruxtecan in Previously Treated HER2-Low Advanced Breast Cancer.”

Reviewed by Hasan Çağrı Yıldırım, MD on Jul 05, 2022

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