Altai Protocol Library

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New Indication: Zanubrutinib in Relapsed or Refractory Chronic Lymphocytic Leukemia (ALPINE)

New Indication: Zanubrutinib in Relapsed or Refractory Chronic Lymphocytic Leukemia (ALPINE)
Study:
  • Phase III, randomized, open-label study
  • Relapsed or refractory CLL/SLL
  • Zanubritinib (n=327) vs. İbrutinib (n=325)
Efficacy:
  • 24 mos PFS: 78.4% vs. 65.9%
  • mPFS: NR vs. 34.2 mos, HR:0.65, p=0.002
  • ORR: 86.2% vs 75.7%
Safety:
  • Grade≥3 AEs: neutropenia (16% vs. 13.9%), hypertension (14.8% vs. 11.1%), Covid-19 related pneumonia (7.1% vs. 4.0%)

N Engl J Med 2023; 388:319-332

Brown R.J et al. ¨Zanubrutinib or Ibrutinib in Relapsed or Refractory Chronic Lymphocytic Leukemia¨

http://doi.org/0.1056/NEJMoa2211582

Reviewed by Elvin CHALABİYEV, MD on FEB 24, 2023

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