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New Indication: Zanubrutinib versus bendamustine and rituximab in untreated chronic lymphocytic leukaemia and small lymphocytic lymphoma (SEQUOIA)

New Indication: Zanubrutinib versus bendamustine and rituximab in untreated chronic lymphocytic leukaemia and small lymphocytic lymphoma (SEQUOIA)
Study:
  • Open-label, multicentre, phase 3 study
  • Untreated CLL or SLL
  • Patients without del (17) (p13·1)  zanubrutinib (group A; n=241) or bendamustine–rituximab (group B; n=238) and patients with del(17) (p13·1) zanubrutinib
Efficacy:
  • mPFS was significantly improved in group A versus group B (HR 0·42 [95% CI 0·28 – 0·63]; p<0·0001)
  • 24 months PFS: 85·5% in group A and 69·5% in group B
  • ORR: 94·6% in group A and 85·3% in group B
  • CR rate: 7% in group A and 15% in group B
Safety:
  • Grade 1-2 any AEs: 41% vs 16% (group A vs group B)
  • Grade ≥3 AEs neutropenia 11% vs 51%, infections 16% vs 19%
  • Grade 1-2 all bleeding AE: 41% vs 9%

Lancet Oncol. 2022 Aug;23(8):1031-1043.

Tam CS, Brown JR, Kahl BS, et al. Zanubrutinib versus bendamustine and rituximab in untreated chronic lymphocytic leukaemia and small lymphocytic lymphoma (SEQUOIA): a randomised, controlled, phase 3 trial

https://doi.org/10.1016/s1470-2045(22)00293-5

Reviewed by Hasan Çağrı Yıldırım, MD on Aug 16, 2022

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