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New Protocol – A Phase 2 Study of Pemigatinib in Patients with Myeloid/Lymphoid Neoplasms with Fibroblast Growth Factor Receptor 1 Rearrangement 8 (FIGHT-203)

New Protocol – A Phase 2 Study of Pemigatinib in Patients with Myeloid/Lymphoid Neoplasms with Fibroblast Growth Factor Receptor 1 Rearrangement 8 (FIGHT-203)
Study:
  • Phase 2, open label, multicenter trial
  • Myeloid/Lymphoid Neoplasms  28 patients
  • ≥1 prior therapy  Pemigatinib 13.5 mg daily (2 wks; 1 wk off)
  • No prior therapy Pemigatinib 13.5 mg daily (continuous)
Efficacy:
  • In patients with chronic phase (N = 18): CR: 83%
  • In patients with blast phase (N=13): CR: 38%
Safety:
  • Any grade AEs: hyperphosphatemia (74%), nail toxicity (62%), alopecia (59%), stomatitis (53%), diarrhea (50%), dry eye (50%), fatigue (44%), rash (35%), abdominal pain (35%), anemia (35%), constipation (32%), dry mouth (32%), epistaxis (29%), retinal pigment epithelial detachment (26%), extremity pain (26%)

Blood 2021; 138 (Supplement 1): 385.

Jason Gotlib, Jean-Jacques Kiladjian, Alessandro Vannucchi, Alessandro Rambaldi, Andreas Reiter, William Shomali, Tracy I. George, Jay L. Patel, Philomena Colucci, Chris Walker, Huiling Zhen, Srdan Verstovsek; A Phase 2 Study of Pemigatinib (FIGHT-203; INCB054828) in Patients with Myeloid/Lymphoid Neoplasms (MLNs) with Fibroblast Growth Factor Receptor 1 (FGFR1) Rearrangement (MLN FGFR1).

https://doi.org/10.1182/blood-2021-148103

Reviewed by Hasan Çağrı Yıldırım, MD on Sep 28, 2022

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