Altai Protocol Library

1041 protocols and counting

All protocols with references and links

All protocols reviewed by a Medical Oncologist/Hematologist

All protocols in major guidelines included

Ability to create your own protocols

Kütüphanede Ara Ara

New Protocol: Abiraterone plus prednisone added to androgen deprivation therapy and docetaxel in de novo metastatic castration-sensitive prostate cancer 

New Protocol: Abiraterone plus prednisone added to androgen deprivation therapy and docetaxel in de novo metastatic castration-sensitive prostate cancer 
Study:
  • Open-label, randomised, phase 3 study (PEACE-1)
  • De novo metastatic prostate adenocarcinoma
  • Standard of care (androgen deprivation therapy alone or with intravenous docetaxel 75 mg/m2 once every 3 weeks, N:296), standard of care plus radiotherapy (N:293), standard of care plus abiraterone (N:292), or standard of care plus radiotherapy plus abiraterone (N:291)
Efficacy:
  • Patients assigned to receive abiraterone (n=583) had longer radiographic PFS [HR:0·54, 0·41–0·71; p<0·0001] and OS [0·82, 0·69–0·98; p=0·030] than patients who did not receive abiraterone (n=589)
  • mOS: 5·72 years vs 4·72 years (abiraterone plus SOC vs SOC)
Safety:
  • Grade >= 3 AEs : 63% vs 52% (abiraterone, ADT plus docetaxel vs ADT plus docetaxel), hypertencion (22% vs 13%)

Lancet. 2022 Apr 30;399(10336):1695-1707.

Fizazi, Karim et al. “Abiraterone plus prednisone added to androgen deprivation therapy and docetaxel in de novo metastatic castration-sensitive prostate cancer (PEACE-1): a multicentre, open-label, randomised, phase 3 study with a 2 × 2 factorial design.

https://doi.org/10.1016/s0140-6736(22)00367-1

Reviewed by Hasan Çağrı Yıldırım, MD on May 30, 2022

Altai Chemo Planner

Quickly Prepare Accurate Chemotherapy Orders

Altai Chemo Planner employs Altai Protocol Library that includes over 1000 chemotherapy protocols for both Hematology and Oncology. You can find major guidelines' protocols, parenteral, and oral, in the library. Altai Protocol Library is frequently and regularly updated.

Learn More