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New Protocol: Axitinib and Avelumab in Patients with Recurrent/Metastatic Adenoid Cystic Carcinoma (ACC)

New Protocol: Axitinib and Avelumab in Patients with Recurrent/Metastatic Adenoid Cystic Carcinoma (ACC)
Study:
  • Open-label, single-arm, phase 2 study
  • Pretreated metastatic or recurrent ACC
  • Axitinib + Avelumab q28 (n=28)
Efficacy:
  • ORR: 21% [8.3%-41.0%]
  • mPFS: 7.3 mos [3.7-11.2 mos]
  • mOS: 16.6 mos [12.4-NR]
Safety:
  • Any grade AEs: Fatigue (62%), diarrhea (32%), hypertension (32%), mucositis (29%)
  • Grad≥ AEs: Hypertension (9%), fatigue (6%), palmar-plantar erythrodysesthesia (6%)

J Clin Oncol 2023; 28 MAR

Ferrarotto Renata et al. Phase II Clinical Trial of Axitinib and Avelumab in Patients With Recurrent/Metastatic Adenoid Cystic Carcinoma

http://doi.org/10.1200/JCO.22.02221

Reviewed by Elvin CHALABİYEV, MD on APR 17, 2023

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