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New Protocol: Bortezomib-Dexamethasone, Rituximab, and Cyclophosphamide as First-Line Treatment for Waldenström’s Macroglobulinemia

New Protocol: Bortezomib-Dexamethasone, Rituximab, and Cyclophosphamide as First-Line Treatment for Waldenström’s Macroglobulinemia
Study:
  • Prospectively Randomized , phase 3 trial
  • Treatment naïve Waldenström’s macroglobulinemia (WM)
  • Bortezomib, dexamethasone, rituximab, and cyclophosphamide (B-DRC ) vs. DRC
Efficacy:
  • 24 mos PFS: 80.6 vs 72.8 %, p=0.320
  • Major response: 80.6 vs 69.9%
  • CR/very good PR: 17.2 vs. 9.6%
Safety:
  • Grade≥3 AEs: Peripheral sensory neuropathy ( 2 pts vs. 0 pts)

JCO 2023; 10 FEB

Buske C. et al. ¨ Bortezomib-Dexamethasone, Rituximab, and Cyclophosphamide as First-Line Treatment for Waldenström’s Macroglobulinemia: A Prospectively Randomized Trial of the European Consortium for Waldenström’s Macroglobulinemia¨

https://doi.org/10.1200/JCO.22.01805

Reviewed by Elvin CHALABİYEV, MD on FEB 24, 2023

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