Altai Protocol Library

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New Protocol: Copanlisib + riTUXimab for indolent NHL

New Protocol: Copanlisib + riTUXimab for indolent NHL
  • Double-blind, randomized, placebo-controlled phase III trial (CHRONOS-3)
  • CD20+ indolent non-Hodgkin lymphoma relapsed after last anti-CD20 containing therapy
  • Copanlisib + riTUXimab vs. placebo + riTUXimab
  • CR: 34% vs. 15%
  • ORR: 81% vs. 48%
  • Median DoR: 20.4 vs. 17.3 mos
  • Median PFS: 21.5 vs. 13.8 mos (HR: 0.52 [0.39-0.69])
  • OS @ 3yr: 83% vs. 81%
  • Grade >=3 AEs: hyperglycemia (54% vs. 8%), hypertension (40% vs. 9%), neutropenia (16% vs. 12%), pneumonia (6% vs. 3%)

Lancet Oncol 2021; 22: 678–89

Matasar MJ, et al. Copanlisib plus rituximab versus placebo plus rituximab in patients with relapsed indolent non-Hodgkin lymphoma (CHRONOS-3): a double-blind, randomised, placebo-controlled, phase 3 trial

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Altai Chemo Planner employs Altai Protocol Library that includes over 1000 chemotherapy protocols for both Hematology and Oncology. You can find major guidelines' protocols, parenteral, and oral, in the library. Altai Protocol Library is frequently and regularly updated.

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