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New Protocol: Daratumumab, Carfilzomib, Lenalidomide, and Dexamethasone with Minimal Residual Disease Response-Adapted Therapy in Newly Diagnosed Multiple Myeloma

New Protocol: Daratumumab, Carfilzomib, Lenalidomide, and Dexamethasone with Minimal Residual Disease Response-Adapted Therapy in Newly Diagnosed Multiple Myeloma
Study:
  • Multicenter, single-arm, phase II trial
  • Newly diagnosed multiple myeloma (N:123)
  • High-risk cytogenetic abnormalities: 0:56 1:46 2:24 patients
  • Daratumumab, carfilzomib, lenalidomide, and dexamethasone (Dara-KRd) plus AHCT, and Dara-KRd consolidation
Efficacy:
  • MRD negativity: 80%
  • MRD < 10–6: 66%
  • 2-year-PFS: 87% (91%, 97%, and 58% for patients with 0, 1, and 2+ HRCA)
  • 2-year-OS: 94%
Safety:
  • Any AEs: 100%, fatigue:55%, bone pain:55%, rash:41%, neutropenia:41%, lymphopenia:28%
  • Grade ≥3 AEs neutropenia 35%, lymphopenia:22%, hypertension:10%

J Clin Oncol. 2022 Sep 1;40(25):2901-2912.

Costa LJ, Chhabra S, Medvedova E, et al. Daratumumab, Carfilzomib, Lenalidomide, and Dexamethasone With Minimal Residual Disease Response-Adapted Therapy in Newly Diagnosed Multiple Myeloma.

https://doi.org/10.1200/jco.21.01935

Reviewed by Hasan Çağrı Yıldırım, MD on Sep 27, 2022

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