Altai Protocol Library

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New Protocol – Durvalumab plus Gemcitabine and Cisplatin in Advanced Biliary Tract Cancer

New Protocol – Durvalumab plus Gemcitabine and Cisplatin in Advanced Biliary Tract Cancer
Study:
  • Double-blind, placebo-controlled, phase 3 study
  • Untreated unresectable or metastatic biliary tract cancer
  • Gemcitabine – cisplatin plus Durvalumab (341) or placebo (344)
Efficacy:
  • 24 month OS: 24.9% vs. 10.4%
  • ORR: 26.7% vs. 18.7%
  • mPFS: 7.2 mos vs. 5.7 mos (HR:0.75, P=0.001)
  • DOR: 7.3 mos vs. 5.8 mos
Safety:
  • Any grade AEs: 99.4% vs 98.8%, anemia:48.2%-44.7%, nausea: 40.2%-34.2, neutropenia:31.7%-31%
  • Grade ≥3 AEs: 75.7% vs 77.8%
  • Deaths due to adverse events: 3.6% vs 4.1%
  • Immune-mediated AEs: 12.7% – 4.7%

NEJM Evid 2022; 1 (8)

Do-Youn Oh, Aiwu Ruth He, Shukui Qin, M.D. et al. Durvalumab plus Gemcitabine and Cisplatin in Advanced Biliary Tract Cancer

https://doi.org/10.1056/EVIDoa2200015

Reviewed by Hasan Çağrı Yıldırım, MD on Sep 27, 2022

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Altai Chemo Planner employs Altai Protocol Library that includes over 1000 chemotherapy protocols for both Hematology and Oncology. You can find major guidelines' protocols, parenteral, and oral, in the library. Altai Protocol Library is frequently and regularly updated.

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