1. Home /
    2. Altai Protocol Library /
  2. New Protocol: Epcoritamab-bysp for relapsed or refractory diffuse large B-cell lymphoma and high-grade B-cell lymphoma

Altai Protocol Library

1041 protocols and counting

All protocols with references and links

All protocols reviewed by a Medical Oncologist/Hematologist

All protocols in major guidelines included

Ability to create your own protocols

Search Library Posts Search
Altai Protocol Library

New Protocol: Epcoritamab-bysp for relapsed or refractory diffuse large B-cell lymphoma and high-grade B-cell lymphoma

New Protocol: Epcoritamab-bysp for relapsed or refractory diffuse large B-cell lymphoma and high-grade B-cell lymphoma
Study:
  • Phase1/2, open-label, multi-cohort, multicenter, single-arm trial (EPCORE NHL-1)
  • Relapsed or refractory DLBCL, not otherwise specified, including DLBCL arising from indolent lymphoma, and high-grade B-cell lymphoma after two or more lines of systemic therapy, including at least one anti-CD20 monoclonal antibody-containing therapy
  • Epcoritamab-bysp q28 (n=157)
Efficacy:
  • cORR: 61% [96 of 157 pts]
  • CR: 38% [60 of 157 pts]
  • mDOR: 15.6 mos [9.7-NR]
Safety:
  • Any Grade Aes: CRS (51%), ICANS (6%)
  • Grade≥3 AEs: CRS (2.5%), ICANS (0.6%)

DOI: 10.1200/JCO.2023.41.16_suppl.7525 Journal of Clinical Oncology 41, no. 16_suppl (June 01, 2023) 7525-7525.

Karimi et al. Effect of follow-up time on the ability of subcutaneous epcoritamab to induce deep and durable complete remissions in patients with relapsed/refractory large B-cell lymphoma: Updated results from the pivotal EPCORE NHL-1 trial.

https://www.fda.gov/drugs/drug-approvals-and-databases/fda-grants-accelerated-approval-epcoritamab-bysp-relapsed-or-refractory-diffuse-large-b-cell

Reviewed by Elvin CHALABİYEV, MD on JUN 10, 2023

Altai Chemo Planner

Quickly Prepare Accurate Chemotherapy Orders

Altai Chemo Planner employs Altai Protocol Library that includes over 1000 chemotherapy protocols for both Hematology and Oncology. You can find major guidelines' protocols, parenteral, and oral, in the library. Altai Protocol Library is frequently and regularly updated.

Learn More