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New Protocol: Ibrutinib and rituximab for patients with previously untreated chronic lymphocytic leukemia (CLL)

New Protocol: Ibrutinib and rituximab for patients with previously untreated chronic lymphocytic leukemia (CLL)
Study:
  • Phase III, randomized,controlled, multicenter, open-label trial (FLAIR)
  • Treatment naive CLL–small lymphocytic lymphoma (SLL)
  • İbrutinib + Rituximab (n=386) vs. FCR (n=385)
Efficacy:
  • mPFS: NR vs. 67 mos, p<0.0001
  • 4-year PFS: 85.6% vs. 73%
  • mOS: NR vs. NR
  • 4-year OS: 92.1% vs.93.5%
Safety:
  • Grade≥3 AEs: Anemia (4% vs. 14%), white blood cell decreased (14% vs.54%), sepsis (2% vs.12%), fever (1% vs.10%)

Lancet Oncol VOL 24, ISSUE 5, P535-552, MAY 2023

Hillmen P. et al. Ibrutinib and rituximab versus fludarabine, cyclophosphamide, and rituximab for patients with previously untreated chronic lymphocytic leukaemia (FLAIR): interim analysis of a multicentre, open-label, randomized, phase 3 trial

http://doi.org/10.1016/S1470-2045(23)00144-4

Reviewed by Elvin CHALABİYEV, MD on MAY 10, 2023

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