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New Protocol: Irinotecan – cetuximab + vemurafenib in bRAF-mutated colorectal cancer

New Protocol: Irinotecan – cetuximab + vemurafenib in bRAF-mutated colorectal cancer

Open-label, randomized phase II trial
Metastatic or unresectable colorectal cancer with bRAF-V600E mutation. Received one or more systemic therapy before
Irinotecan – cetuximab + placebo (n=50) vs. Irinotecan – cetuximab + vemurafenib (n=50)
ORR: 4% vs. 17%
Median PFS: 2.0 vs. 4.2 mos. PFS HR: 0.50 [0.32-0.76]
Grade 3-4 AEs: Diarrhea, anorexia, anemia, febrile neutropenia, hypokalemia, nausea, neutropenia

J Clin Oncol 2020 Dec 23. Online ahead of print.
Kopetz S, et al. Randomized Trial of Irinotecan and Cetuximab With or Without Vemurafenib in BRAF-Mutant Metastatic Colorectal Cancer (SWOG S1406)
https://doi.org/10.1200/JCO.20.01994

Reviewed by Ulas Darda Bayraktar, MD on Jan 12, 2021

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