Altai Protocol Library

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New Protocol: Irinotecan – cetuximab + vemurafenib in bRAF-mutated colorectal cancer

New Protocol: Irinotecan – cetuximab + vemurafenib in bRAF-mutated colorectal cancer
Study:
  • Open-label, randomized phase II trial
  • Metastatic or unresectable colorectal cancer with bRAF-V600E mutation. Received one or more systemic therapy before
  • Irinotecan – cetuximab + placebo (n=50) vs. Irinotecan – cetuximab + vemurafenib (n=50)
Efficacy:
  • ORR: 4% vs. 17%
  • Median PFS: 2.0 vs. 4.2 mos. PFS HR: 0.50 [0.32-0.76]
Safety:
  • Grade 3-4 AEs: Diarrhea, anorexia, anemia, febrile neutropenia, hypokalemia, nausea, neutropenia

J Clin Oncol 2020 Dec 23. Online ahead of print.

Kopetz S, et al. Randomized Trial of Irinotecan and Cetuximab With or Without Vemurafenib in BRAF-Mutant Metastatic Colorectal Cancer (SWOG S1406)

https://doi.org/10.1200/JCO.20.01994

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Altai Chemo Planner employs Altai Protocol Library that includes over 1000 chemotherapy protocols for both Hematology and Oncology. You can find major guidelines' protocols, parenteral, and oral, in the library. Altai Protocol Library is frequently and regularly updated.

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